diff --git a/python/tox.ini b/python/tox.ini
index 849e66a1e..fc67b22d3 100644
--- a/python/tox.ini
+++ b/python/tox.ini
@@ -6,7 +6,10 @@
 # as building that from source takes a very long time)
 
 [tox]
-envlist = py{36,37,38,39,310}-{minimal,default,full}
+envlist =
+    py{36,37,38,39,310}-{minimal,default,full}
+    py{36,37,38,39,310}-click{7,80}
+    py{37,38,39,310}-click81
 
 [testenv]
 deps =
@@ -24,3 +27,13 @@ commands =
     trezorctl --help
     # Run test suite
     !minimal: pytest --random-order tests
+
+[testenv:py{36,37,38,39,310}-click{7,80,81}]
+deps =
+    -rrequirements.txt
+    click7: click>=7,<8
+    click80: click>=8.0,<8.1
+    click81: click>=8.1,<8.2
+commands =
+    # Smoke-test trezorctl
+    trezorctl --version