diff --git a/core/.changelog.d/4351.changed.3 b/core/.changelog.d/4351.changed.3
new file mode 100644
index 0000000000..87cd7c8ae5
--- /dev/null
+++ b/core/.changelog.d/4351.changed.3
@@ -0,0 +1 @@
+Forbid per-node paths in multisig change outputs and multisig receive addresses.
diff --git a/core/src/apps/bitcoin/sign_tx/change_detector.py b/core/src/apps/bitcoin/sign_tx/change_detector.py
index b668206437..3f88e52c5e 100644
--- a/core/src/apps/bitcoin/sign_tx/change_detector.py
+++ b/core/src/apps/bitcoin/sign_tx/change_detector.py
@@ -46,6 +46,18 @@ class ChangeDetector:
         if txo.script_type not in common.CHANGE_OUTPUT_SCRIPT_TYPES:
             return False
 
+        if txo.multisig and not common.multisig_uses_single_path(txo.multisig):
+            # An address that uses different derivation paths for different xpubs
+            # could be difficult to discover if the user did not note all the paths.
+            # The reason is that each path ends with an address index, which can
+            # have 1,000,000 possible values. If the address is a t-out-of-n
+            # multisig, the total number of possible paths is 1,000,000^n. This can
+            # be exploited by an attacker who has compromised the user's computer.
+            # The attacker could randomize the address indices and then demand a
+            # ransom from the user to reveal the paths. To prevent this, we require
+            # that all xpubs use the same derivation path.
+            return False
+
         return (
             self.multisig_fingerprint.output_matches(txo)
             and self.wallet_path.output_matches(txo)
diff --git a/tests/device_tests/bitcoin/test_multisig_change.py b/tests/device_tests/bitcoin/test_multisig_change.py
index 990c92c82e..9703a9b672 100644
--- a/tests/device_tests/bitcoin/test_multisig_change.py
+++ b/tests/device_tests/bitcoin/test_multisig_change.py
@@ -406,6 +406,43 @@ def test_multisig_mismatch_multisig_change(client: Client):
         )
 
 
+# inputs match, change mismatches (second tries to be change but isn't)
+@pytest.mark.models(skip="legacy", reason="Not fixed")
+def test_multisig_mismatch_multisig_change_different_paths(client: Client):
+    multisig_out2 = messages.MultisigRedeemScriptType(
+        pubkeys=[
+            messages.HDNodePathType(node=NODE_EXT1, address_n=[1, 0]),
+            messages.HDNodePathType(node=NODE_EXT2, address_n=[1, 1]),
+            messages.HDNodePathType(node=NODE_INT, address_n=[1, 2]),
+        ],
+        signatures=[b"", b"", b""],
+        m=2,
+    )
+
+    out1 = messages.TxOutputType(
+        address="3B23k4kFBRtu49zvpG3Z9xuFzfpHvxBcwt",
+        amount=40_000_000,
+        script_type=messages.OutputScriptType.PAYTOADDRESS,
+    )
+
+    out2 = messages.TxOutputType(
+        address_n=[H_(45), 0, 1, 2],
+        multisig=multisig_out2,
+        amount=44_000_000,
+        script_type=messages.OutputScriptType.PAYTOMULTISIG,
+    )
+
+    with client:
+        client.set_expected_responses(_responses(client, INP1, INP2))
+        btc.sign_tx(
+            client,
+            "Bitcoin",
+            [INP1, INP2],
+            [out1, out2],
+            prev_txes=TX_API,
+        )
+
+
 # inputs mismatch, change matches with first input
 def test_multisig_mismatch_inputs(client: Client):
     multisig_out1 = messages.MultisigRedeemScriptType(