diff --git a/core/embed/trezorhal/sdcard.c b/core/embed/trezorhal/sdcard.c
index dd228fd688..6b298f7b66 100644
--- a/core/embed/trezorhal/sdcard.c
+++ b/core/embed/trezorhal/sdcard.c
@@ -214,7 +214,9 @@ uint64_t sdcard_get_capacity_in_bytes(void) {
 
 void SDIO_IRQHandler(void) {
   IRQ_ENTER(SDIO_IRQn);
-  HAL_SD_IRQHandler(&sd_handle);
+  if (sd_handle.Instance) {
+    HAL_SD_IRQHandler(&sd_handle);
+  }
   IRQ_EXIT(SDIO_IRQn);
 }
 
diff --git a/core/embed/trezorhal/usbd_conf.c b/core/embed/trezorhal/usbd_conf.c
index 26fdf00c38..798d332adc 100644
--- a/core/embed/trezorhal/usbd_conf.c
+++ b/core/embed/trezorhal/usbd_conf.c
@@ -706,12 +706,20 @@ void  USBD_LL_Delay(uint32_t Delay)
   */
 #if defined(USE_USB_FS)
 void OTG_FS_IRQHandler(void) {
-    HAL_PCD_IRQHandler(&pcd_fs_handle);
+    IRQ_ENTER(OTG_FS_IRQn);
+    if (pcd_fs_handle.Instance) {
+        HAL_PCD_IRQHandler(&pcd_fs_handle);
+    }
+    IRQ_EXIT(OTG_FS_IRQn);
 }
 #endif
 #if defined(USE_USB_HS)
 void OTG_HS_IRQHandler(void) {
-    HAL_PCD_IRQHandler(&pcd_hs_handle);
+    IRQ_ENTER(OTG_HS_IRQn);
+    if (pcd_hs_handle.Instance) {
+        HAL_PCD_IRQHandler(&pcd_hs_handle);
+    }
+    IRQ_EXIT(OTG_HS_IRQn);
 }
 #endif
 
@@ -760,18 +768,24 @@ static void OTG_CMD_WKUP_Handler(PCD_HandleTypeDef *pcd_handle) {
   */
 #if defined(USE_USB_FS)
 void OTG_FS_WKUP_IRQHandler(void) {
-    OTG_CMD_WKUP_Handler(&pcd_fs_handle);
-
+    IRQ_ENTER(OTG_FS_WKUP_IRQn);
+    if (pcd_fs_handle.Instance) {
+        OTG_CMD_WKUP_Handler(&pcd_fs_handle);
+    }
     /* Clear EXTI pending Bit*/
     __HAL_USB_OTG_FS_WAKEUP_EXTI_CLEAR_FLAG();
+    IRQ_EXIT(OTG_FS_WKUP_IRQn);
 }
 #endif
 #if defined(USE_USB_HS)
 void OTG_HS_WKUP_IRQHandler(void) {
-    OTG_CMD_WKUP_Handler(&pcd_hs_handle);
-
+    IRQ_ENTER(OTG_HS_WKUP_IRQn);
+    if (pcd_hs_handle.Instance) {
+        OTG_CMD_WKUP_Handler(&pcd_hs_handle);
+    }
     /* Clear EXTI pending Bit*/
     __HAL_USB_HS_EXTI_CLEAR_FLAG();
+    IRQ_EXIT(OTG_HS_WKUP_IRQn);
 }
 #endif