diff --git a/.travis.yml b/.travis.yml
index f4246bb..0302d5b 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -1,32 +1,26 @@
 language: python
 matrix:
-  allow_failures:
-    - env: TOX_ENV=squeeze
   include:
-    - python: 2.6
-      env: TOX_ENV=py26
     - python: 2.7
       env: TOX_ENV=py27
-    - python: 3.3
-      env: TOX_ENV=py33
     - python: 3.4
       env: TOX_ENV=py34
     - python: 3.5
       env: TOX_ENV=py35
     - python: 3.6
       env: TOX_ENV=py36
-    - python: 2.6
-      env: TOX_ENV=squeeze
     - python: 2.7
       env: TOX_ENV=wheezy
 install:
   - pip install -U pip
-  - pip install tox
-  - pip install pyflakes
+  - pip install flake8 tox
   - sudo rm -rf /dev/shm && sudo ln -s /run/shm /dev/shm
 script:
   - tox -e $TOX_ENV
-  - python -m pyflakes.__main__ $(git ls-files | grep -E "^isso/.+.py$" | grep -v "^isso/compat.py")
+  # stop the build if there are Python syntax errors or undefined names
+  - flake8 . --count --select=E901,E999,F821,F822,F823 --show-source --statistics
+  # exit-zero treats all errors as warnings.  The GitHub editor is 127 chars wide
+  - flake8 . --count --exit-zero --max-complexity=10 --max-line-length=127 --statistics
 notifications:
   irc:
     channels:
diff --git a/docs/docs/install.rst b/docs/docs/install.rst
index 688b050..8ce4f8c 100644
--- a/docs/docs/install.rst
+++ b/docs/docs/install.rst
@@ -79,7 +79,7 @@ Install from PyPi
 Requirements
 ^^^^^^^^^^^^
 
-- Python 2.6, 2.7 or 3.3+ (+ devel headers)
+- Python 2.7 or 3.4+ (+ devel headers)
 - SQLite 3.3.8 or later
 - a working C compiler
 
@@ -157,7 +157,7 @@ Install from Source
 If you want to hack on Isso or track down issues, there's an alternate
 way to set up Isso. It requires a lot more dependencies and effort:
 
-- Python 2.6, 2.7 or 3.3+ (+ devel headers)
+- Python 2.7 or 3.4+ (+ devel headers)
 - Virtualenv
 - SQLite 3.3.8 or later
 - a working C compiler
diff --git a/isso/compat.py b/isso/compat.py
index e12f268..e38ecc5 100644
--- a/isso/compat.py
+++ b/isso/compat.py
@@ -1,28 +1,22 @@
 # -*- encoding: utf-8 -*-
 
-import sys
-PY2K = sys.version_info[0] == 2
-
-if not PY2K:
-
-    map, zip, filter = map, zip, filter
-    from functools import reduce
-
-    iteritems = lambda dikt: iter(dikt.items())
-
+try:
+    text_type = unicode  # Python 2
+    string_types = (str, unicode)
+    PY2K = True
+except NameError:        # Python 3
+    PY2K = False
     text_type = str
     string_types = (str, )
 
+if not PY2K:
     buffer = memoryview
+    filter, map, zip = filter, map, zip
+    iteritems = lambda dikt: iter(dikt.items())  # noqa: E731
+    from functools import reduce
 else:
-
-    from itertools import imap, izip, ifilter
-    map, zip, filter = imap, izip, ifilter
-    reduce = reduce
-
-    iteritems = lambda dikt: dikt.iteritems()
-
-    text_type = unicode
-    string_types = (str, unicode)
-
     buffer = buffer
+    from itertools import ifilter, imap, izip
+    filter, map, zip = ifilter, imap, izip
+    iteritems = lambda dikt: dikt.iteritems()   # noqa: E731
+    reduce = reduce
diff --git a/isso/config.py b/isso/config.py
index 234a0fe..c2a05ce 100644
--- a/isso/config.py
+++ b/isso/config.py
@@ -17,11 +17,6 @@ from isso.compat import text_type as str
 logger = logging.getLogger("isso")
 
 
-# Python 2.6 compatibility
-def total_seconds(td):
-    return (td.microseconds + (td.seconds + td.days * 24 * 3600) * 10**6) / 10**6
-
-
 def timedelta(string):
     """
     Parse :param string: into :class:`datetime.timedelta`, you can use any
@@ -101,7 +96,7 @@ class IssoParser(ConfigParser):
             try:
                 return int(delta.total_seconds())
             except AttributeError:
-                return int(total_seconds(delta))
+                return int(delta.total_seconds())
 
     def getlist(self, section, key):
         return list(map(str.strip, self.get(section, key).split(',')))
diff --git a/isso/tests/test_comments.py b/isso/tests/test_comments.py
index 1e2bdf1..e7bc011 100644
--- a/isso/tests/test_comments.py
+++ b/isso/tests/test_comments.py
@@ -5,11 +5,7 @@ from __future__ import unicode_literals
 import os
 import json
 import tempfile
-
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
+import unittest
 
 try:
     from urllib.parse import urlencode
diff --git a/isso/tests/test_config.py b/isso/tests/test_config.py
index dc40e65..2fd1b4d 100644
--- a/isso/tests/test_config.py
+++ b/isso/tests/test_config.py
@@ -1,10 +1,6 @@
 # -*- encoding: utf-8 -*-
 
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
-
+import unittest
 import io
 
 from isso import config
diff --git a/isso/tests/test_cors.py b/isso/tests/test_cors.py
index 4cfc20d..415ea51 100644
--- a/isso/tests/test_cors.py
+++ b/isso/tests/test_cors.py
@@ -1,10 +1,7 @@
 
 from __future__ import unicode_literals
 
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
+import unittest
 
 from werkzeug.test import Client
 from werkzeug.wrappers import Response
diff --git a/isso/tests/test_db.py b/isso/tests/test_db.py
index 54b9122..74e0831 100644
--- a/isso/tests/test_db.py
+++ b/isso/tests/test_db.py
@@ -1,10 +1,6 @@
 # -*- encoding: utf-8 -*-
 
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
-
+import unittest
 import os
 import sqlite3
 import tempfile
diff --git a/isso/tests/test_guard.py b/isso/tests/test_guard.py
index fca932c..a9ae365 100644
--- a/isso/tests/test_guard.py
+++ b/isso/tests/test_guard.py
@@ -2,11 +2,7 @@
 
 from __future__ import unicode_literals
 
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
-
+import unittest
 import os
 import json
 import tempfile
diff --git a/isso/tests/test_html.py b/isso/tests/test_html.py
index b1be6dc..362e239 100644
--- a/isso/tests/test_html.py
+++ b/isso/tests/test_html.py
@@ -1,10 +1,6 @@
 # -*- encoding: utf-8 -*-
 
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
-
+import unittest
 import textwrap
 
 from isso import config
diff --git a/isso/tests/test_migration.py b/isso/tests/test_migration.py
index 7b73d75..8a876ee 100644
--- a/isso/tests/test_migration.py
+++ b/isso/tests/test_migration.py
@@ -2,11 +2,7 @@
 
 from __future__ import unicode_literals
 
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
-
+import unittest
 import tempfile
 from os.path import join, dirname
 
diff --git a/isso/tests/test_utils.py b/isso/tests/test_utils.py
index 88668f4..0504c15 100644
--- a/isso/tests/test_utils.py
+++ b/isso/tests/test_utils.py
@@ -1,10 +1,6 @@
 # -*- encoding: utf-8 -*-
 
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
-
+import unittest
 
 from isso import utils
 from isso.utils import parse
diff --git a/isso/tests/test_utils_hash.py b/isso/tests/test_utils_hash.py
index 626d75e..18a790e 100644
--- a/isso/tests/test_utils_hash.py
+++ b/isso/tests/test_utils_hash.py
@@ -2,10 +2,7 @@
 
 from __future__ import unicode_literals
 
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
+import unittest
 
 from isso import config
 
@@ -70,4 +67,4 @@ class TestCreate(unittest.TestCase):
         pbkdf2 = _new("pbkdf2:16:2:md5")
         self.assertIsInstance(pbkdf2, PBKDF2)
         self.assertEqual(pbkdf2.dklen, 2)
-        self.assertEqual(pbkdf2.func, "md5")
\ No newline at end of file
+        self.assertEqual(pbkdf2.func, "md5")
diff --git a/isso/tests/test_vote.py b/isso/tests/test_vote.py
index f6817a0..4045ccb 100644
--- a/isso/tests/test_vote.py
+++ b/isso/tests/test_vote.py
@@ -4,11 +4,7 @@ from __future__ import unicode_literals
 import os
 import json
 import tempfile
-
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
+import unittest
 
 from werkzeug.wrappers import Response
 
diff --git a/isso/tests/test_wsgi.py b/isso/tests/test_wsgi.py
index 17e0b12..254b51e 100644
--- a/isso/tests/test_wsgi.py
+++ b/isso/tests/test_wsgi.py
@@ -1,10 +1,6 @@
 # -*- encoding: utf-8 -*-
 
-try:
-    import unittest2 as unittest
-except ImportError:
-    import unittest
-
+import unittest
 
 from isso import wsgi
 
diff --git a/setup.py b/setup.py
index b2c7482..ef866fe 100644
--- a/setup.py
+++ b/setup.py
@@ -5,10 +5,13 @@ import sys
 
 from setuptools import setup, find_packages
 
-requires = ['itsdangerous', 'misaka>=1.0,<2.0', 'html5lib==0.9999999', 'Jinja2']
+requires = ['html5lib==0.9999999', 'itsdangerous', 'Jinja2',
+            'misaka>=1.0,<2.0', 'werkzeug>=0.9']
 
-if (3, 0) <= sys.version_info < (3, 3):
-    raise SystemExit("Python 3.0, 3.1 and 3.2 are not supported")
+if sys.version_info < (2, 7):
+    raise SystemExit("Python 2 versions < 2.7 are not supported.")
+elif (3, 0) <= sys.version_info < (3, 4):
+    raise SystemExit("Python 3 versions < 3.4 are not supported.")
 
 setup(
     name='isso',
@@ -27,16 +30,14 @@ setup(
         "Topic :: Internet :: WWW/HTTP :: HTTP Servers",
         "Topic :: Internet :: WWW/HTTP :: WSGI :: Application",
         "License :: OSI Approved :: MIT License",
-        "Programming Language :: Python :: 2.6",
         "Programming Language :: Python :: 2.7",
-        "Programming Language :: Python :: 3.3",
-        "Programming Language :: Python :: 3.4"
+        "Programming Language :: Python :: 3.4",
+        "Programming Language :: Python :: 3.5",
+        "Programming Language :: Python :: 3.6"
     ],
     install_requires=requires,
     extras_require={
-        ':python_version=="2.6"': ['argparse', 'ordereddict'],
-        ':python_version=="2.6" or python_version=="2.7"': ['ipaddr>=2.1', 'configparser', 'werkzeug>=0.8'],
-        ':python_version!="2.6" and python_version!="2.7"': ['werkzeug>=0.9']
+        ':python_version=="2.7"': ['ipaddr>=2.1', 'configparser']
     },
     entry_points={
         'console_scripts':
diff --git a/tox.ini b/tox.ini
index 5b8b90a..bb55662 100755
--- a/tox.ini
+++ b/tox.ini
@@ -1,5 +1,5 @@
 [tox]
-envlist = py27,py33,py34,py35,py36
+envlist = py27,py34,py35,py36
 
 [testenv]
 deps =
@@ -8,14 +8,6 @@ deps =
 commands =
     python setup.py nosetests
 
-[testenv:py26]
-deps =
-    argparse
-    unittest2
-    ordereddict
-    configparser
-    {[testenv]deps}
-
 [testenv:py27]
 deps =
     configparser
@@ -30,12 +22,6 @@ deps=
     passlib==1.5.3
     werkzeug==0.8.3
 
-[testenv:squeeze]
-basepython=python2.6
-deps=
-    {[testenv:py26]deps}
-    {[testenv:debian]deps}
-
 [testenv:wheezy]
 basepython=python2.7
 deps =