diff --git a/dispatch.py b/dispatch.py
new file mode 100644
index 0000000..08758c6
--- /dev/null
+++ b/dispatch.py
@@ -0,0 +1,63 @@
+
+import os
+import logging
+
+try:
+    from urlparse import urlparse
+except ImportError:
+    from urllib.parse import urlparse
+
+from werkzeug.exceptions import ImATeapot
+
+from isso import make_app, wsgi
+from isso.core import Config
+
+logger = logging.getLogger("isso")
+
+
+class Dispatcher(object):
+    """
+    A dispatcher to support different websites. Dispatches based on
+    HTTP-Host. If HTTP-Host is not provided, display an error message.
+    """
+
+    def __init__(self, *confs):
+
+        self.isso = {}
+
+        for conf in map(Config.load, confs):
+
+            app = make_app(conf)
+
+            for origin in conf.getiter("general", "host"):
+                self.isso[origin.rstrip("/")] = app
+
+    def __call__(self, environ, start_response):
+
+        if "HTTP_ORIGIN" in environ:
+            origin = environ["HTTP_ORIGIN"]
+        elif "HTTP_REFERER" in environ:
+            rv = urlparse(environ["HTTP_REFERER"])
+            origin = rv.scheme + "://" + rv.hostname + (":" + str(rv.port) if rv.port else "")
+        else:
+            origin = wsgi.host(environ)
+
+        try:
+            # logger.info("dispatch %s", origin)
+            return self.isso[origin](environ, start_response)
+        except KeyError:
+            # logger.info("unable to dispatch %s", origin)
+            resp = ImATeapot("unable to dispatch %s" % origin)
+            return resp(environ, start_response)
+
+
+if "ISSO_SETTINGS" not in os.environ:
+    logger.fatal('no such environment variable: ISSO_SETTINGS')
+else:
+    confs = os.environ["ISSO_SETTINGS"].split(";")
+    for path in confs:
+        if not os.path.isfile(path):
+            logger.fatal("%s: no such file", path)
+            break
+    else:
+        application = Dispatcher(*confs)
diff --git a/docs/CONFIGURATION.rst b/docs/CONFIGURATION.rst
index 67aec97..2ee722d 100644
--- a/docs/CONFIGURATION.rst
+++ b/docs/CONFIGURATION.rst
@@ -208,6 +208,89 @@ reply-to-self
     Do not forget to configure the client.
 
 
+Multiple Sites
+--------------
+
+Isso is designed to serve comments for a single website and therefore stores
+comments for a relative URL to support HTTP, HTTPS and even domain transfers
+without manual intervention. But you can chain Isso to support multiple
+websites on different domains.
+
+The following example uses [gunicorn](http://gunicorn.org/) as WSGI server (you
+can use uWSGI as well). It is *not* possible to run the isso executable for
+multiple sites.
+
+Let's say you maintain two websites, like foo.example and other.foo:
+
+.. code-block:: bash
+
+    $ cat /etc/isso.d/foo.example.cfg
+    [general]
+    host = http://foo.example/
+    dbpath = /var/lib/isso/foo.example.db
+    $ cat /etc/isso.d/other.foo.cfg
+    [general]
+    host = http://other.foo/
+    dbpath = /var/lib/isso/other.foo.db
+    $ export ISSO_SETTINGS="/etc/isso.d/foo.example.cfg;/etc/isso.d/other.foo.cfg"
+    $ gunicorn isso.dispatch -b localhost:8080
+
+Now, there are two options to configure the webserver:
+
+  1. using a single host to serve comments for both websites
+  2. different hosts for both websites
+
+In the former case, Isso dispatches based on the HTTP Referer and (if provided)
+HTTP Origin. If you expect users to supress their referer completely, you
+should use the second option.
+
+1. Using a single host to serve comments.
+
+  .. code-block:: nginx
+
+        server {
+            listen [::]:80;
+            server_name comments.example;
+
+            location / {
+                proxy_pass http://localhost:8080;
+                proxy_set_header X-Forwarded-For $proxy_add_x_forwarded_for;
+                proxy_set_header X-Real-IP $remote_addr;
+            }
+        }
+
+  To verify the setup, run:
+
+  .. code-block:: bash
+
+        $ curl -vH "Origin: http://foo.example" http://comments.example/
+        ...
+        $ curl -vH "Origin: http://other.foo" http://comments.example/
+        ...
+
+  In case of a 418 (I'm a teapot), the setup is *not* correctly configured.
+
+2. Using different hosts for both websites (no need for a dedicated domain,
+     you can also proxy Isso on a sub-uri like /isso).
+
+  .. code-block:: nginx
+
+        server {
+            listen [::]:80;
+            server_name comments.foo.example comments.other.foo;
+
+            location / {
+                proxy_pass http://localhost:8080;
+                proxy_set_header Host $host;
+                proxy_set_header X-Forwarded-For $proxy_add_x_forwarded_for;
+                proxy_set_header X-Real-IP $remote_addr;
+            }
+        }
+
+  No need to verify this setup, here the webserver automatically sets the
+  proper host.
+
+
 Appendum
 ---------